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The researchers found that the risk for a primary outcome event (major kidney disease events, a composite of the onset of kidney failure, at least a 50 percent reduction in the estimated glomerular filtration rate from baseline, or death from kidney-related or cardiovascular causes) was significantly lower in the semaglutide group (331 versus 410 first events
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The extension is not a rationally designed pharmacophore, it is a residual fragment of the methionyl porcine growth hormone fusion partner used to express the protein in Escherichia coli, characterised in a companion paper in the same journal and year
